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Avicenna Journal of Neuro Psycho Phyisology، جلد ۸، شماره ۲، صفحات ۱۰۹-۱۱۴
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عنوان انگلیسی Effects of Intracerebroventricular Micro-injection of Kaempferol on Anxiety: Possible GABAergic Mechanism Involved
چکیده انگلیسی مقاله Background and Objectives: Kaempferol (KM) is one of the most important plants with neuroprotection and analgesic effects. In addition, bicuculline (BIC) is a competitive antagonist of the GABAA ionotropic receptor (the most important targets of benzodiazepines and other anxiety suppressants). In this study, intracerebroventricular microinjection of KM on anxiety and its interaction with GABAergic mechanism were investigated in male rats. Materials and Methods: In this exploratory investigation, the male rats were divided into the following groups: control (saline), groups treated by KM (0.5 and 2 mg/rat), DMSO (1mg/rat), KM 0.5+BIC1 mg/rat, KM 0.5+BIC4 mg/rat, KM 2+BIC1 mg/rat, BIC groups (1, 4 mg/rat), and KM 2+BIC 4 mg/rat. Besides, an elevated plus-maze paradigm was used for the evaluation of the anxiety.   Results: Statistical analysis revealed that the indices of TTOA in KM groups (0.5 and 2 mg/rat) significantly increased in comparison to the control group (P< 0.05 and P< 0.01, respectively). Moreover, regarding the involvement of the GABAergic system in the anxiolytic-like activity of KM, it was demonstrated that the TTOA related to co-administration of KM (0.5mg/rat) with bicuculline (1mg/rat) significantly reduced, compared to the control group (P< 0.05).   Conclusion: According to the obtained results, the use of KM can likely improve anxiety through GABAergic mechanism(s).
کلیدواژه‌های انگلیسی مقاله Anxiety, Bicuculline, GABAergic mechanism, Kaempferol
نویسندگان مقاله | Mohammad Zarei
Department of Physiology, Neurophysiology Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Abdolrahman Sarihi
Department of Physiology, Neurophysiology Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Davoud Ahmadimoghaddam
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran


| Erfan Soltani
Department of Physiology, Neurophysiology Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-274-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anxiety and Stress
نوع مقاله منتشر شده پژوهشی
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