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Avicenna Journal of Neuro Psycho Phyisology، جلد ۱، شماره ۱، صفحات ۰-۰
عنوان فارسی Differential Effects of Sildenafil (Viagra) on Processing Steps of Spatial Learning and Memory in Rat
چکیده فارسی مقاله Background Sildenafil (Viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cGMP). On the other hands, the nitric oxide/cGMP signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (LTP) in the central nervous system considered as a model of learning and memory. Objectives The aim of the present study was to determine the effects of sildenafil on different stages of spatial learning and memory of rat using radial maze. Materials and Methods The effects of pre-training, pre-retrieval oral administration or post-training i.p. injection of sildenafil (10 mg/kg) in radial maze task were investigated. Results Pre-training and post-training administration of sildenafil impaired radial maze task. Pre-retrieval injection of sildenafil decreased reference memory and working memory errors. Therefore, sildenafil impaired acquisition and consolidation of spatial learning and memory but improved retrieval of spatial memory in radial maze. Conclusions Sildenafil has differential effects on the spatial learning and memory processing. It seems this result is due to accumulation of cGMP in the neural structures related to learning and memory processing. As different neural structures are involved in different learning and memory tasks, these results might be due to the different actions of cGMP in different structures of brain.
کلیدواژه‌های فارسی مقاله Sildenafil،Spatial Learning and Memory،Rat
عنوان انگلیسی Differential Effects of Sildenafil (Viagra) on Processing Steps of Spatial Learning and Memory in Rat
چکیده انگلیسی مقاله Background Sildenafil (Viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cGMP). On the other hands, the nitric oxide/cGMP signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (LTP) in the central nervous system considered as a model of learning and memory. Objectives The aim of the present study was to determine the effects of sildenafil on different stages of spatial learning and memory of rat using radial maze. Materials and Methods The effects of pre-training, pre-retrieval oral administration or post-training i.p. injection of sildenafil (10 mg/kg) in radial maze task were investigated. Results Pre-training and post-training administration of sildenafil impaired radial maze task. Pre-retrieval injection of sildenafil decreased reference memory and working memory errors. Therefore, sildenafil impaired acquisition and consolidation of spatial learning and memory but improved retrieval of spatial memory in radial maze. Conclusions Sildenafil has differential effects on the spatial learning and memory processing. It seems this result is due to accumulation of cGMP in the neural structures related to learning and memory processing. As different neural structures are involved in different learning and memory tasks, these results might be due to the different actions of cGMP in different structures of brain.
کلیدواژه‌های انگلیسی مقاله Sildenafil,Spatial Learning and Memory,Rat
نویسندگان مقاله سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran, tel 98-8138380462, fax 98-8138380208

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مهدی ارجی پور | mahdi arjipour
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

علیرضا کمکی | alireza komaki
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مینو محمودی | minoo mahmoodi
department of biology, islamic azad university, hamadan branch, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://www.avicennajnpp.com/index.php?page=article&article_id=18671
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کد مقاله (doi) 10.17795/ajnpp-18671
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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