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Avicenna Journal of Neuro Psycho Phyisology، جلد ۱، شماره ۱، صفحات ۰-۰
عنوان فارسی Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study
چکیده فارسی مقاله Conclusions These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. Results The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Background Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task.
کلیدواژه‌های فارسی مقاله Alzheimer&apos،s disease، Amyloid β-peptide، Learning، Rats
عنوان انگلیسی Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study
چکیده انگلیسی مقاله Conclusions These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. Results The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Background Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task.
کلیدواژه‌های انگلیسی مقاله Alzheimer&apos,s disease, Amyloid β-peptide, Learning, Rats
نویسندگان مقاله علی نیکخواه | ali nikkhah
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

فاطمه ghahremanitamadon | fatemeh ghahremanitamadon
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سمیه zargooshnia | somayeh zargooshnia
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سارا سلیمانی اصل | sara soleimani asl
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; department of anatomy, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran, tel fax 98-8118380208

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://www.avicennajnpp.com/index.php?page=article&article_id=18664
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کد مقاله (doi) 10.17795/ajnpp-18664
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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