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Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۲، صفحات ۰-۰
عنوان فارسی Histamine Potentiates Cyclosomatostatin-Induced Catalepsy in Old Rats
چکیده فارسی مقاله Conclusions CycloSOM and histamine synergistically exert catalepsy in old rats. In light of these data, the combination of the decreased brain level of somatostatin and increased brain level of histamine may be of pathogenic relevance for extrapyramidal signs in PD. Results CycloSOM (0.2, 1.0, and 5.0 µg) and histamine (1.0 and 10.0 µg) alone were ineffective in both young and old animals. In combination, however, cycloSOM and histamine initiated cataleptic response in old rats. Effect of the combination was inhibited by H1 and H2 but not H3 antagonists. Materials and Methods The animals used in the study were 100 - 110 and 736 - 767 days old. Catalepsy was evaluated by the bar test. The inhibition of the brain somatostatin activity was simulated by I.C.V. administration of cyclosomatostatin (cycloSOM), a somatostatin receptor antagonist. Objectives The current study aimed to examine if histamine alters the cataleptogenic activity of the brain somatostatin deficiency in Wistar rats. Background The decreased level of somatostatin and increased level of histamine are detected in the Parkinsonian brain. In old Wistar rats, the brain somatostatin deficiency can initiate catalepsy that suggests the pathogenic significance of this abnormality in Parkinson’s disease (PD). The ability of histamine to affect the somatostatin deficiency action is not studied.
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عنوان انگلیسی Histamine Potentiates Cyclosomatostatin-Induced Catalepsy in Old Rats
چکیده انگلیسی مقاله Conclusions CycloSOM and histamine synergistically exert catalepsy in old rats. In light of these data, the combination of the decreased brain level of somatostatin and increased brain level of histamine may be of pathogenic relevance for extrapyramidal signs in PD. Results CycloSOM (0.2, 1.0, and 5.0 µg) and histamine (1.0 and 10.0 µg) alone were ineffective in both young and old animals. In combination, however, cycloSOM and histamine initiated cataleptic response in old rats. Effect of the combination was inhibited by H1 and H2 but not H3 antagonists. Materials and Methods The animals used in the study were 100 - 110 and 736 - 767 days old. Catalepsy was evaluated by the bar test. The inhibition of the brain somatostatin activity was simulated by I.C.V. administration of cyclosomatostatin (cycloSOM), a somatostatin receptor antagonist. Objectives The current study aimed to examine if histamine alters the cataleptogenic activity of the brain somatostatin deficiency in Wistar rats. Background The decreased level of somatostatin and increased level of histamine are detected in the Parkinsonian brain. In old Wistar rats, the brain somatostatin deficiency can initiate catalepsy that suggests the pathogenic significance of this abnormality in Parkinson’s disease (PD). The ability of histamine to affect the somatostatin deficiency action is not studied.
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نویسندگان مقاله ایلیا d ionov | ilya d ionov
centre on theoretical problems in physical and chemical pharmacology, russian academy of sciences, moscow, russia; centre on theoretical problems in physical and chemical pharmacology, russian academy of sciences, p. o. box 117513, moscow, russia. tel 7-9160734902; fax 7-4954383883


زویا a turgeneva | zoya a turgeneva
research group, timpharm ltd, moscow, russia
نشانی اینترنتی http://www.avicennajnpp.com/index.php?page=article&article_id=31238
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کد مقاله (doi) 10.17795/ajnpp-31238
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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